The blessed effect of the scroll of amnesia allows you to choose the skills (and spells?) you want to forget, which allows you to reskill more efficiently.

Possibly only do this if your Intelligence is sufficiently high.

Reading a noncursed scroll of amnesia while confused “clears your mind”, which cures the confusion and sometimes gives you enlightenment, but the regular amnesia effects still happen too.

You can apply a scroll of amnesia to an item to unidentify that one item. This consumes the scroll.

Dipping a scroll of amnesia into some (or all?) non-polymorph, non-water potions will make the potion “forget itself” and turn to water. The scroll also blanks.